HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity.

ABSTRACT:

Background

Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 pathogenesis is not well-defined. We aimed to investigate if SERINC5 down-regulation activity contributes to HIV-1 subtype C disease progression, to assess the relative contribution of this activity to overall Nef function, and to identify amino acids required for optimal activity. We measured the SERINC5 down-regulation activity of 106 subtype C Nef clones, isolated from individuals in early infection, for which the Nef activities of CD4 and HLA-I down-regulation as well as alteration of TCR signalling were previously measured. The relationship between SERINC5 down-regulation and markers of disease progressio

SUBMITTER: Naicker D 

PROVIDER: S-EPMC10067162 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature