Lifetime changes in body fatness and breast density in postmenopausal women: the FEDRA study.

ABSTRACT: High mammographic breast density (MBD) is an established risk factor for breast cancer (BC). Body fatness conveys an increased BC risk in postmenopause but is associated with less dense breasts. Here, we studied the relationship between body fatness and breast composition within the FEDRA (Florence-EPIC Digital mammographic density and breast cancer Risk Assessment) longitudinal study. Repeated anthropometric data and MBD parameters (obtained through an automated software on BC screening digital mammograms) were available for all participants, as well as information on other BC risk factors. Multivariate linear regression and functional data analysis were used to longitudinally evaluate the association of body fatness, and changes thereof over time, with dense (DV) and non-dense (NDV) brea

SUBMITTER: Masala G 

PROVIDER: S-EPMC10067176 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature