Precise pancreatic cancer therapy through targeted degradation of mutant p53 protein by cerium oxide nanoparticles.

ABSTRACT:

Background

In a significant proportion of cancers, point mutations of TP53 gene occur within the DNA-binding domain, resulting in an abundance of mutant p53 proteins (mutp53) within cells, which possess tumor-promoting properties. A potential and straightforward strategy for addressing p53-mutated cancer involves the induction of autophagy or proteasomal degradation. Based on the previously reported findings, elevating oxidative state in the mutp53 cells represented a feasible approach for targeting mutp53. However, the nanoparticles previous reported lacked sufficient specificity of regulating ROS in tumor cells, consequently resulted in unfavorable toxicity in healthy cells.

Results

We here in showed that cerium oxide CeO₂ nanoparticles (CeO₂ NPs) exh

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10067194 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature