Neuroglobin plays as tumor suppressor by disrupting the stability of GPR35 in colorectal cancer.

ABSTRACT:

Background

The incidence of colorectal cancer (CRC) has increased in recent years. Identification of accurate tumor markers has become the focus of CRC research. Early and frequent DNA methylation tends to occur in cancer. Thus, identifying accurate methylation biomarkers would improve the efficacy of CRC treatment. Neuroglobin (NGB) is involved in neurological and oncological diseases. However, there are currently no reports on epigenetic regulation involvement of NGB in CRC.

Results

NGB was downregulated or silenced in majority CRC tissues and cell lines. The hypermethylation of NGB was detected in tumor tissue, but no or a very low methylation frequency in normal tissues. Overexpression of NGB induced G2/M phase arrest and apoptosis, suppressed proliferation, migration, i

SUBMITTER: Xiang Q 

PROVIDER: S-EPMC10067258 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature