A lipid metabolism-based prognostic risk model for HBV-related hepatocellular carcinoma.

ABSTRACT:

Background

Up to 85% of hepatocellular carcinoma (HCC) cases in China can be attributed to infection of hepatitis B virus (HBV). Lipid metabolism performs important function in hepatocarcinogenesis of HBV-related liver carcinoma. However, limited studies have explored the prognostic role of lipid metabolism in HBV-related HCC. This study established a prognostic model to stratify HBV-related HCC based on lipid metabolisms.

Methods

Based on The Cancer Genome Atlas HBV-related HCC samples, this study selected prognosis-related lipid metabolism genes and established a prognosis risk model by performing uni- and multi-variate Cox regression methods. The final markers used to establish the model were selected through the least absolute shrinkage and selection operator method. Ana

SUBMITTER: Zhou L 

PROVIDER: S-EPMC10067291 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature