Selective serotonin reuptake inhibitors and suicidality in children and young adults: analyses of pharmacovigilance databases.

ABSTRACT:

Background

Since the warnings by the United States (US) and European regulatory authorities in 2004 and 2005 it had been discussed whether there is some link between selective serotonin reuptake inhibitors (SSRIs) and suicidality in the pediatric population. The aim of our study was to describe trends and patterns in spontaneous reporting data referring to suicidality in children, adolescents and young adults treated with SSRI after the warnings.

Methods

Descriptive analyses of reports for 0-24 year olds referring to suicide/suicidal ideations, self-harms and overdoses with SSRIs reported as suspected submitted to the US (FAERS) and the European (EudraVigilance) adverse drug reaction databases until 2019 were performed. The causal relationship was assessed in accordance with

SUBMITTER: Dubrall D 

PROVIDER: S-EPMC10067298 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature