Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation.

ABSTRACT:

Background

A wide spectrum of changes occurs in the brain with age, from molecular to morphological aspects, and inflammation accompanied by mitochondria dysfunction is one of the significant factors associated with age. Adiponectin (APN), an essential adipokine in glucose and lipid metabolism, is involved in the aging; however, its role in brain aging has not been adequately explored. Here, we aimed to explore the relationship between APN deficiency and brain aging using multiple biochemical and pharmacological methods to probe APN in humans, KO mice, primary microglia, and BV2 cells.

Results

We found that declining APN levels in aged human subjects correlated with dysregulated cytokine levels, while APN KO mice exhibited accelerated aging accompanied by learning and memory

SUBMITTER: He K 

PROVIDER: S-EPMC10067304 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature