Polygenic risk score for attention-deficit/hyperactivity disorder and brain functional networks segregation in a community-based sample.

ABSTRACT: Neuroimaging studies suggest that brain development mechanisms might explain at least some behavioural and cognitive attention-deficit/hyperactivity disorder (ADHD) symptoms. However, the putative mechanisms by which genetic susceptibility factors influence clinical features via alterations of brain development remain largely unknown. Here, we set out to integrate genomics and connectomics tools by investigating the associations between an ADHD polygenic risk score (ADHD-PRS) and functional segregation of large-scale brain networks. With this aim, ADHD symptoms score, genetic and rs-fMRI (resting-state functional magnetic resonance image) data obtained in a longitudinal community-based cohort of 227 children and adolescents were analysed. A follow-up was conducted approximately 3 years aft

SUBMITTER: Sato JR 

PROVIDER: S-EPMC10067387 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature