HNF1B-driven three-dimensional chromatin structure for molecular classification in pancreatic cancers.

ABSTRACT: The molecular subtypes of pancreatic cancer (PC), either classical/progenitor-like or basal/squamous-like, are currently a major topic of research because of their direct association with clinical outcomes. Some transcription factors (TFs) have been reported to be associated with these subtypes. However, the mechanisms by which these molecular signatures of PCs are established remain unknown. Epigenetic regulatory processes, supported by dynamic changes in the chromatin structure, are essential for transcriptional profiles. Previously, we reported the importance of open chromatin profiles in the biological features and transcriptional status of PCs. Here, we aimed to analyze the relationships between three-dimensional (3D) genome structures and the molecular subtypes of human PCs using Hi-

SUBMITTER: Kato H 

PROVIDER: S-EPMC10067390 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature