A genome-wide association study identified new variants associated with mathematical abilities in Chinese children.

ABSTRACT: Mathematical ability is moderately heritable, and it is a complex trait which can be evaluated in several different categories. A few genetic studies have been published on general mathematical ability. However, no genetic study focused on specific mathematical ability categories. In this study, we separately performed genome-wide association studies on 11 mathematical ability categories in 1146 students from Chinese elementary schools. We identified seven genome-wide significant single nucleotide polymorphisms (SNPs) with strong linkage disequilibrium among each other (all r²  > 0.8) associated with mathematical reasoning ability (top SNP: rs34034296, p = 2.01 × 10^-8 , nearest gene: CUB and Sushi multiple domains 3, CSMD3). We replicated one SNP (rs133885) from 585 S

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10067424 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature