Protein therapy of skeletal muscle atrophy and mechanism by angiogenic factor AGGF1.

ABSTRACT:

Background

Skeletal muscle atrophy is a common condition without a pharmacologic therapy. AGGF1 encodes an angiogenic factor that regulates cell differentiation, proliferation, migration, apoptosis, autophagy and endoplasmic reticulum stress, promotes vasculogenesis and angiogenesis and successfully treats cardiovascular diseases. Here, we report the important role of AGGF1 in the pathogenesis of skeletal muscle atrophy and attenuation of muscle atrophy by AGGF1.

Methods

In vivo studies were carried out in impaired leg muscles from patients with lumbar disc herniation, two mouse models for skeletal muscle atrophy (denervation and cancer cachexia) and heterozygous Aggf1^+/- mice. Mouse muscle atrophy phenotypes were characterized by body weight and myotube cross-sec

SUBMITTER: He Z 

PROVIDER: S-EPMC10067473 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature