Effects of a 2-year exercise training on neuromuscular system health in older individuals with low muscle function.

ABSTRACT:

Background

Ageing is accompanied by a progressive loss of skeletal muscle mass and strength, potentially determining the insurgence of sarcopenia. Evidence suggests that motoneuron and neuromuscular junction (NMJ) degeneration contribute to sarcopenia pathogenesis. Seeking for strategies able to slow down sarcopenia insurgence and progression, we investigated whether a 2-year mixed-model training involving aerobic, strength and balance exercises would be effective for improving or preserving motoneuronal health and NMJ stability, together with muscle mass, strength and functionality in an old, sarcopenic population.

Methods

Forty-five sarcopenic elderly (34 females; 11 males) with low dual-energy X-ray absorptiometry (DXA) lean mass and Short Physical Performance Battery (SP

SUBMITTER: Monti E 

PROVIDER: S-EPMC10067485 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature