Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis.

ABSTRACT:

Background

Late-life aging is often associated with appetite reduction and weight loss. Physical activity (PA) may prevent these processes, but the molecular mechanisms involved remain elusive. The present study investigated the putative mediating aspect of growth differentiation factor 15 (GDF-15), a stress signalling protein involved in aging, exercise and appetite control, on the association between PA and late-life-associated weight loss.

Methods

One thousand eighty-three healthy adults (63.8% women) aged 70 years and over who participated in the Multidomain Alzheimer Preventive Trial were included. Bodyweight (kg) and PA levels (square root of metabolic equivalent of task-min/week) were assessed repeatedly from baseline to the 3-year visit, whereas plasma GDF-15 (pg/mL)

SUBMITTER: Raffin J 

PROVIDER: S-EPMC10067491 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature