Nicotinamide Phosphoribosyltransferase-elevated NAD⁺ biosynthesis prevents muscle disuse atrophy by reversing mitochondrial dysfunction.

ABSTRACT:

Background

It is well known that muscle disuse atrophy is associated with mitochondrial dysfunction, which is implicated in reduced nicotinamide adenine dinucleotide (NAD⁺ ) levels. Nicotinamide phosphoribosyltransferase (NAMPT), a rate-limiting enzyme in NAD⁺ biosynthesis, may serve as a novel strategy to treat muscle disuse atrophy by reversing mitochondrial dysfunction.

Methods

To investigate the effects of NAMPT on the prevention of disuse atrophy of skeletal muscles predominantly composed of slow-twitch (type I) or fast-twitch (type II) fibres, rabbit models of rotator cuff tear-induced supraspinatus muscle atrophy and anterior cruciate ligament (ACL) transection-induced extensor digitorum longus (EDL) atrophy were established and then administered

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10067495 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature