Dietary phosphate restriction prevents the appearance of sarcopenia signs in old mice.

ABSTRACT:

Background

Sarcopenia is defined by the progressive and generalized loss of muscle mass and function associated with aging. We have previously proposed that aging-related hyperphosphataemia is linked with the appearance of sarcopenia signs. Because there are not effective treatments to prevent sarcopenia, except for resistance exercise, we propose here to analyse whether the dietary restriction of phosphate could be a useful strategy to improve muscle function and structure in an animal model of aging.

Methods

Five-month-old (young), 24-month-old (old) and 28-month-old (geriatric) male C57BL6 mice were used. Old and geriatric mice were divided into two groups, one fed with a standard diet (0.6% phosphate) and the other fed with a low-phosphate (low-P) diet (0.2% phosphate) f

SUBMITTER: Alcalde-Estevez E 

PROVIDER: S-EPMC10067497 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature