Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models.

ABSTRACT: Skeletal muscle wasting, whether related to physiological ageing, muscle disuse or to an underlying chronic disease, is a key determinant to quality of life and mortality. However, cellular basis responsible for increased catabolism in myocytes often remains unclear. Although myocytes represent the vast majority of skeletal muscle cellular population, they are surrounded by numerous cells with various functions. Animal models, mostly rodents, can help to decipher the mechanisms behind this highly dynamic process, by allowing access to every muscle as well as time-course studies. Satellite cells (SCs) play a crucial role in muscle regeneration, within a niche also composed of fibroblasts and vascular and immune cells. Their proliferation and differentiation is altered in several models of m

SUBMITTER: Henrot P 

PROVIDER: S-EPMC10067506 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature