A novel 7-chemokine-genes predictive signature for prognosis and therapeutic response in renal clear cell carcinoma.

ABSTRACT: Background: Renal clear cell carcinoma (ccRCC) is one of the most prevailing type of malignancies, which is affected by chemokines. Chemokines can form a local network to regulate the movement of immune cells and are essential for tumor proliferation and metastasis as well as for the interaction between tumor cells and mesenchymal cells. Establishing a chemokine genes signature to assess prognosis and therapy responsiveness in ccRCC is the goal of this effort. Methods: mRNA sequencing data and clinicopathological data on 526 individuals with ccRCC were gathered from the The Cancer Genome Atlas database for this investigation (263 training group samples and 263 validation group samples). Utilizing the LASSO algorithm in conjunction with univariate Cox analysis, the gene signat

SUBMITTER: Lin MJ 

PROVIDER: S-EPMC10067584 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature