MCP-1 levels in astrocyte-derived exosomes are changed in preclinical stage of Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common form of dementia in older adults. There is accumulating evidence that inflammatory processes play a critical role in AD pathogenesis. In this study, we investigated whether inflammatory factors in plasma and astrocyte-derived exosomes (ADEs) from plasma are differentially expressed in the early stages of AD and their potential role in pathological processes in the AD continuum.

Method

We included 39 normal controls (NCs), 43 participants with subjective cognitive decline (SCD), and 43 participants with amnestic mild cognitive impairment (aMCI)/AD. IL-6, IL-8, and MCP-1 in plasma and ADEs from plasma were evaluated using a commercial multiplex Luminex-based kit.

Results

Pairwise comparisons between the groups showe

SUBMITTER: Wang T 

PROVIDER: S-EPMC10067608 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature