Contribution of GalU to biofilm formation, motility, antibiotic and serum resistance, and pathogenicity of Salmonella Typhimurium.

ABSTRACT:

Introduction

Salmonella Typhimurium is the leading cause of foodborne illnesses in China, resulting in major epidemics and economic losses in recent years. Uridine diphosphate-glucose pyrophosphorylase galU plays an important role in thebiosynthesis of the bacterial envelope. Herein, we evaluated the role of galU in S. Typhimurium infection in chicken.

Methods

A galU gene mutant was successfully constructed by red homologous recombination technology, and biological characteristics were studied.

Results

The galU mutant strain had a rough phenotype;was defective in biofilm formation, autoagglutination, and motility; exhibited greater sensitivity to most antibiotics, serum, and egg albumen; and had lowercapacity for adhesion to c

SUBMITTER: Guo L 

PROVIDER: S-EPMC10067927 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature