Association of circulating serum free bioavailable and total vitamin D with cathelicidin levels among active TB patients and household contacts.

ABSTRACT: The free hormone hypothesis postulates that the estimation of free circulating 25 (OH)D may be a better marker of vitamin D status and is of clinical importance compared to total vitamin D fraction. The unbound fraction is involved in biological activities since it is able to penetrate into the cell. Studies have shown that cathelicidin/LL-37 inhibits the growth of Mycobacterium tuberculosis in a vitamin D-dependent manner and therefore adequate vitamin D is required for its expression. The study aimed to determine the association between serum bioavailable and total vitamin D with LL-37 levels in ATB patients, LTBI, and individuals with no TB infection. This was a cross-sectional study in which bioavailable vitamin D and LL-37 levels were measured using competitive ELISA kits and total vi

SUBMITTER: Acen EL 

PROVIDER: S-EPMC10067953 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature