Axl alleviates DSS-induced colitis by preventing dysbiosis of gut microbiota.

ABSTRACT: Axl is a tyrosine kinase receptor, a negative regulator for innate immune responses and inflammatory bowel disease (IBD). The gut microbiota regulates intestinal immune homeostasis, but the role of Axl in the pathogenesis of IBD through the regulation of gut microbiota composition remains unresolved. In this study, mice with DSS-induced colitis showed increased Axl expression, which was almost entirely suppressed by depleting the gut microbiota with antibiotics. Axl^-/- mice without DSS administration exhibited increased bacterial loads, especially the Proteobacteria abundant in patients with IBD, significantly consistent with DSS-induced colitis mice. Axl^-/- mice also had an inflammatory intestinal microenvironment with reduced antimicrobial peptides and overexpressio

SUBMITTER: Yee SM 

PROVIDER: S-EPMC10067963 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature