Circulating maternal prorenin and oocyte and preimplantation embryo development: the Rotterdam Periconception Cohort.

ABSTRACT:

Study question

Could circulating maternal prorenin serve as a proxy for oocyte and preimplantation embryo development, assessed by time-lapse parameters and clinical treatment outcomes?

Summary answer

High circulating maternal prorenin concentrations after ovarian stimulation associate with a larger oocyte area, faster cleavage divisions from the five-cell stage onwards and increased chance of successful implantation.

What is known already

After ovarian stimulation, circulating prorenin (renin's precursor), is largely ovary-derived. Prorenin may contribute to ovarian angiotensin synthesis, which is relevant in reproduction given its role in follicular development and oocyte maturation.

Study design, size, duration

Prospective observational cohort study includin

SUBMITTER: Wiegel RE 

PROVIDER: S-EPMC10068267 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature