Racial differences in transcriptomics and reactive oxygen species burden in myometrium and leiomyoma.

ABSTRACT:

Study question

Are there differences in Mediator Complex Subunit 12 mutations (MED12) mutation, transcriptomics, and protein expression in uterine myometrium and leiomyomas of Black and White women?

Summary answer

RNA sequencing, tissue microarray, and immunohistochemistry data revealed that Black and White women have significant differences in their myometrium and leiomyoma profiles.

What is known already

Black women develop uterine leiomyoma earlier than White women, and are more likely to be anemic, have multiple tumors, undergo hysterectomy at an earlier age, have a higher uterine weight, and report very severe pelvic pain.

Study design, size, duration

Uterine tissues were collected from premenopausal women undergoing hysterectomy or myomectomy at Northwest

SUBMITTER: Li Y 

PROVIDER: S-EPMC10068273 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature