Cortisol/glucocorticoid receptor: a critical mediator of the ovulatory process and luteinization in human periovulatory follicles.

ABSTRACT:

Study question

Do cortisol/glucocorticoid receptors play an active role in the human ovary during ovulation and early luteinization?

Summary answer

The ovulatory hCG stimulation-induced glucocorticoid receptor signaling plays a crucial role in regulating steroidogenesis and ovulatory cascade in human periovulatory follicles.

What is known already

Previous studies reported an increase in cortisol levels in the human follicular fluid after the LH surge or ovulatory hCG administration. However, little is known about the role of cortisol/glucocorticoid receptors in the ovulatory process and luteinization in humans.

Study design, size, duration

This study was an experimental prospective clinical and laboratory-based study. An in vivo experimental study was accomplis

SUBMITTER: Jeon H 

PROVIDER: S-EPMC10068287 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature