Functional and structural features of L2/3 pyramidal cells continuously covary with pial depth in mouse visual cortex.

ABSTRACT: Pyramidal cells of neocortical layer 2/3 (L2/3 PyrCs) integrate signals from numerous brain areas and project throughout the neocortex. These PyrCs show pial depth-dependent functional and structural specializations, indicating participation in different functional microcircuits. However, whether these depth-dependent differences result from separable PyrC subtypes or whether their features display a continuum correlated with pial depth is unknown. Here, we assessed the stimulus selectivity, electrophysiological properties, dendritic morphology, and excitatory and inhibitory connectivity across the depth of L2/3 in the binocular visual cortex of mice. We find that the apical, but not the basal dendritic tree structure, varies with pial depth, which is accompanied by variation in subthresho

SUBMITTER: Weiler S 

PROVIDER: S-EPMC10068292 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature