A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling.

ABSTRACT: Osteoclasts are bone-resorbing polykaryons responsible for skeletal remodeling during health and disease. Coincident with their differentiation from myeloid precursors, osteoclasts undergo extensive transcriptional and metabolic reprogramming in order to acquire the cellular machinery necessary to demineralize bone and digest its interwoven extracellular matrix. While attempting to identify new regulatory molecules critical to bone resorption, we discovered that murine and human osteoclast differentiation is accompanied by the expression of Zeb1, a zinc-finger transcriptional repressor whose role in normal development is most frequently linked to the control of epithelial-mesenchymal programs. However, following targeting, we find that Zeb1 serves as an unexpected regulator of osteoclast e

SUBMITTER: Zhu L 

PROVIDER: S-EPMC10068323 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature