Ontology highlight
ABSTRACT:
SUBMITTER: Kramer L
PROVIDER: S-EPMC10068336 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Krämer Lena L Dalheimer Niko N Räschle Markus M Storchová Zuzana Z Pielage Jan J Boos Felix F Herrmann Johannes M JM
The EMBO journal 20230127 7
Hundreds of nucleus-encoded mitochondrial precursor proteins are synthesized in the cytosol and imported into mitochondria in a post-translational manner. However, the early processes associated with mitochondrial protein targeting remain poorly understood. Here, we show that in Saccharomyces cerevisiae, the cytosol has the capacity to transiently store mitochondrial matrix-destined precursors in dedicated deposits that we termed MitoStores. Competitive inhibition of mitochondrial protein import ...[more]