Ontology highlight
ABSTRACT:
SUBMITTER: Lee M
PROVIDER: S-EPMC10068345 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Lee Mirae M Woo Jiwon J Kim Sang Tae ST Moon Minho M Kim Sang Yun SY Cho Hanna H Kim Sujin S Kim Han-Kyeol HK Park Jeong-Yoon JY
BMB reports 20230301 2
We propose a novel blood biomarker detection method that uses miRNA super-resolution imaging to enable the early diagnosis of Alzheimer's disease (AD). Here, we report a singlemolecule detection method for visualizing disease-specific miRNA in tissue from an AD mice model, and peripheral blood mononuclear cells (PBMCs) from AD patients. Using optimized Magnified Analysis of Proteome (MAPs), we confirmed that five miRNAs contribute to neurodegenerative disease in the brain hippocampi of 5XFAD and ...[more]