Population pharmacokinetics and CSF penetration of flucytosine in adults with HIV-associated cryptococcal meningoencephalitis.

ABSTRACT:

Background

There are limited data describing clinical flucytosine pharmacokinetics (PK). The variability of flucytosine partitioning into the CNS is not known. We described the interindividual variability in flucytosine PK in patients with HIV-associated cryptococcal meningoencephalitis. In addition, we quantified the extent and variability of CSF partitioning of flucytosine.

Methods

A PK study was conducted in 64 patients with confirmed HIV-associated cryptococcal meningoencephalitis in Blantyre, Malawi. A four-compartment PK model was developed, and Monte Carlo simulations were performed with flucytosine administered at different doses and in different schedules.

Results

The estimated mean apparent volume of the central compartment was 17.50 (SD 9.99) L; mean appare

SUBMITTER: Stott KE 

PROVIDER: S-EPMC10068416 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature