Facile synthesis of pyrazolopyridine pharmaceuticals under mild conditions using an algin-functionalized silica-based magnetic nanocatalyst (Alg@SBA-15/Fe₃O₄).

ABSTRACT: Pyrazolopyridines are common scaffolds in various bioactive compounds, which have several therapeutic effects and unique pharmacological properties. In this study, we fabricated a novel environmentally friendly silica-based nanocomposite as a multifunctional catalytic system for the synthesis of pyrazolopyridine derivatives. This novel heterogeneous nanocomposite named Alg@SBA-15/Fe₃O₄ (Alg stands for alginic acid), was prepared in several steps. In this regard, SBA-15 was synthesized by the hydrothermal method. Next, it was magnetized by Fe₃O₄ nanoparticles via an in situ co-precipitation process. Then, SBA-15/Fe₃O₄ particles were functionalized with 3-minopropyltriethoxysilane (APTES). Afterward, Alg@SBA-15/F

SUBMITTER: Hassanzadeh-Afruzi F 

PROVIDER: S-EPMC10068431 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature