Clonal hematopoiesis with DNMT3A mutation is associated with lower white matter hyperintensity volume.

ABSTRACT:

Background

Clonal hematopoiesis of indeterminate potential (CHIP) increases the risk of cerebrovascular events, while its association with cerebral white matter hyperintensity (WMH) is undemonstrated. We evaluated the effect of CHIP and its major driving mutations on cerebral WMH severity.

Methods

From an institutional cohort of a routine health check-up program with a DNA repository database, subjects who were ≥50 years of age, with one or more cardiovascular risk factors but no central nervous system disorder, and performed brain MRI were included. Along with the presence of CHIP and its major driving mutations, clinical and laboratory data were obtained. WMH volume was measured in total, periventricular, and subcortical regions.

Results

Among the total 964 subjects

SUBMITTER: Lee WJ 

PROVIDER: S-EPMC10068463 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature