Effect of magnesium sulfate with ketamine infusions on intraoperative and postoperative analgesia in cancer breast surgeries: a randomized double-blind trial.

ABSTRACT:

Background

Opioids are the cornerstone in managing postoperative pain; however, they have many side effects. Ketamine and Magnesium (Mg) are NMDA receptor antagonists used as adjuvant analgesics to decrease postoperative opioid consumption.

Objective

We assumed that adding Mg to ketamine infusion can improve the intraoperative and postoperative analgesic efficacy of ketamine infusion alone in cancer breast surgeries.

Methods

Ninety patients aged between 18 and 65 years and undergoing elective cancer breast surgery were included in this prospective randomized, double-blind study. Group K received ketamine 0.5.ßmg.kg^...1 bolus then 0.12.ßmg.kg^...1.h^...1 infusion for the first 24.ßhours postoperatively. Group KM: received ketamine 0.5.ßmg

SUBMITTER: Hassan ME 

PROVIDER: S-EPMC10068526 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature