Development of a flexible film made of polyvinyl alcohol with chitosan based thermosensitive hydrogel.

ABSTRACT:

Background/purpose

A challenge that arises with periodontal regeneration surgery has been associated with the future development of periodontal regeneration membrane to prevent gingiva and fibroblasts invade the wound and allow alveolar bone successfully regenerated.

Materials and methods

Chitosan (CS) has the advantages of non-toxicity, biodegradation, biocompatibility, and has been widely used in wound dressings. A flexible film was made using polyvinyl alcohol (PVA) blending CS based thermosensitive hydrogel.

Results

The proposed 2% PVA/CS hydrogel has the highest swelling ratio about 720% after 60 min incubation and keeps its area after 10 min incubation for surgery suture. The elastic modulus of 0%, 1%, 2%, and 4% PVA/CS hydrogel were 7.75 ± 1.96, 0.91 ± 0.16, 0.

SUBMITTER: Huang CL 

PROVIDER: S-EPMC10068578 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature