Metabolomic profiling of glucose homeostasis in African Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS-FS).

ABSTRACT:

Introduction

African Americans are at increased risk for type 2 diabetes.

Objectives

This work aimed to examine metabolomic signature of glucose homeostasis in African Americans.

Methods

We used an untargeted liquid chromatography-mass spectrometry metabolomic approach to comprehensively profile 727 plasma metabolites among 571 African Americans from the Insulin Resistance Atherosclerosis Family Study (IRAS-FS) and investigate the associations between these metabolites and both the dynamic (S_I, insulin sensitivity; AIR, acute insulin response; DI, disposition index; and S_G, glucose effectiveness) and basal (HOMA-IR and HOMA-B) measures of glucose homeostasis using univariate and regularized regression models. We also compared the results with our

SUBMITTER: Okut H 

PROVIDER: S-EPMC10068644 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature