Investigating the genetic pathways of insomnia in Autism Spectrum Disorder.

ABSTRACT:

Background

Sleep problems are common in children with autism spectrum disorder (autism). There is sparse research to date to examine whether insomnia in people with autism is related to autism genetics or insomnia genetics. Moreover, there is a lack of research examining whether circadian-rhythm related genes share potential pathways with autism.

Aims

To address this research gap, we tested whether polygenic scores of insomnia or autism are related to risk of insomnia in people with autism, and whether the circadian genes are associated with insomnia in people with autism.

Methods and procedures

We tested these questions using the phenotypically and genotypically rich MSSNG dataset (N = 1049) as well as incorporating in the analyses data from the Vanderbilt University

SUBMITTER: Niarchou M 

PROVIDER: S-EPMC10068748 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature