Urinary complement profile in IgA nephropathy and its correlation with the clinical and pathological characteristics.

ABSTRACT:

Background and objectives

The activated complement profile in IgA nephropathy (IgAN) is still unclear. Our study investigated the profile of urinary complements in IgAN patients and its correlations with clinical and pathological characteristics.

Methods

Urinary protein abundance was detected by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in 50 IgAN, 50 membranous nephropathy (MN), and 68 healthy controls (HC). Then, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to identify differentially expressed proteins in IgAN patients. The differentially expressed complement proteins were screened in IgAN patients, and their correlations with laboratory or pathological parameters were analyzed. Thereafter, 7 complement compo

SUBMITTER: Wang D 

PROVIDER: S-EPMC10068869 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature