Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation.

ABSTRACT: The development of technologies to protect or enhance memory in older people is an enduring goal of translational medicine. Here we describe repetitive (4-day) transcranial alternating current stimulation (tACS) protocols for the selective, sustainable enhancement of auditory-verbal working memory and long-term memory in 65-88-year-old people. Modulation of synchronous low-frequency, but not high-frequency, activity in parietal cortex preferentially improved working memory on day 3 and day 4 and 1 month after intervention, whereas modulation of synchronous high-frequency, but not low-frequency, activity in prefrontal cortex preferentially improved long-term memory on days 2-4 and 1 month after intervention. The rate of memory improvements over 4 days predicted the size of memory benefits 1

SUBMITTER: Grover S 

PROVIDER: S-EPMC10068908 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature