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Functional cooperation between IK_Ca and TRPC1 channels regulates serum-induced vascular smooth muscle cell proliferation via mediating Ca²⁺ influx and ERK1/2 activation.

ABSTRACT: The increased proliferation of vascular smooth muscle cells (VSMCs) contributes to the pathogenesis of vascular diseases. The intermediate conductance calcium-activated potassium (IK_Ca ) channel plays a critical role in VSMC proliferation by raising the intracellular calcium concentration ([Ca²⁺ ]_i ), but the underlying mechanism is still not unclear. Here we investigated the cooperation between IK_Ca and transient receptor potential canonical 1 (TRPC1) channels in mediating extracellular Ca²⁺ entry, which in turn activates downstream Ca²⁺ signalling in the regulation of VSMC proliferation using serum-induced cell proliferation model. Serum-induced cell proliferation was accompanied with up-regulation of IK_Ca expre

SUBMITTER: Jia X

PROVIDER: S-EPMC10068941 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Dataset Information

Functional cooperation between IK_Ca and TRPC1 channels regulates serum-induced vascular smooth muscle cell proliferation via mediating Ca²⁺ influx and ERK1/2 activation.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Functional cooperation between IKCa and TRPC1 channels regulates serum-induced vascular smooth muscle cell proliferation via mediating Ca2+ influx and ERK1/2 activation.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Functional cooperation between IK_Ca and TRPC1 channels regulates serum-induced vascular smooth muscle cell proliferation via mediating Ca²⁺ influx and ERK1/2 activation.