Ontology highlight
ABSTRACT:
SUBMITTER: Huang L
PROVIDER: S-EPMC10068960 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Huang Liuyan L Li Feifei F Ye Ling L Yu Fanyuan F Wang Chenglin C
Cell proliferation 20230201 4
Dynamic chromatin accessibility regulates stem cell fate determination and tissue homeostasis via controlling gene expression. As a histone-modifying enzyme that predominantly mediates methylation of lysine 27 in histone H3 (H3K27me1/2/3), Polycomb repressive complex 2 (PRC2) plays the canonical role in targeting developmental regulators during stem cell differentiation and transformation. Embryonic ectoderm development (EED), the core scaffold subunit of PRC2 and as an H3K27me3-recognizing prot ...[more]