Identification of serum exosomal metabolomic and proteomic profiles for remote ischemic preconditioning.

ABSTRACT:

Background

Remote ischemic preconditioning (RIPC) refers to a brief episode of exposure to potential adverse stimulation and prevents injury during subsequent exposure. RIPC has been shown to increase tolerance to ischemic injury and improve cerebral perfusion status. Exosomes have a variety of activities, such as remodeling the extracellular matrix and transmitting signals to other cells. This study aimed to investigate the potential molecular mechanism of RIPC-mediated neuroprotection.

Methods

Sixty adult male military personnel participants were divided into the control group (n = 30) and the RIPC group (n = 30). We analyzed the differential metabolites and proteins in the serum exosomes of RIPC participants and control subjects.

Results

Eighty-seven differentially

SUBMITTER: Du Y 

PROVIDER: S-EPMC10069038 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature