Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules.

ABSTRACT: The functionalization of material surfaces with biologically active molecules is crucial for enabling technologies in life sciences, biotechnology, and medicine. However, achieving biocompatibility and bioorthogonality with current synthetic methods remains a challenge. We report herein a novel surface functionalization method that proceeds chemoselectively and without a free transition metal catalyst. In this method, a coating is first formed via the tyrosinase-catalyzed putative polymerization of a tetrazine-containing catecholamine (DOPA-Tet). One or more types of molecule of interest containing trans-cyclooctene are then grafted onto the coating via tetrazine ligation. The entire process proceeds under physiological conditions and is suitable for grafting bioactive molecules wit

SUBMITTER: Hast K 

PROVIDER: S-EPMC10069157 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature