RCT versus real-world cohorts: Differences in patient characteristics drive associations with outcome after EVT.

ABSTRACT:

Background

The selection of patients with large-vessel occlusion (LVO) stroke for endovascular treatment (EVT) depends on patient characteristics and procedural metrics. The relation of these variables to functional outcome after EVT has been assessed in numerous datasets from both randomized controlled trials (RCT) and real-world registries, but whether differences in their case mix modulate outcome prediction is unknown.

Methods

We leveraged data from individual patients with anterior LVO stroke treated with EVT from completed RCTs from the Virtual International Stroke Trials Archive (N = 479) and from the German Stroke Registry (N = 4079). Cohorts were compared regarding (i) patient characteristics and procedural pre-EVT metrics, (ii) these variables' relati

SUBMITTER: Quandt F 

PROVIDER: S-EPMC10069173 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature