European Stroke Organisation (ESO) expedited recommendation on tenecteplase for acute ischaemic stroke.

ABSTRACT: Within the last year, four randomised-controlled clinical trials (RCTs) have been published comparing intravenous thrombolysis (IVT) with tenecteplase and alteplase in acute ischaemic stroke (AIS) patients with a non-inferiority design for three of them. An expedited recommendation process was initiated by the European Stroke Organisation (ESO) and conducted according to ESO standard operating procedure based on the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework. We identified three relevant Population, Intervention, Comparator, Outcome (PICO) questions, performed systematic reviews of the literature and meta-analyses, assessed the quality of the available evidence, and wrote evidence-based recommendations. Expert consensus statements were provided if

SUBMITTER: Alamowitch S 

PROVIDER: S-EPMC10069183 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature