Association of cholesterol levels with hemorrhagic transformation and cerebral edema after reperfusion therapies.

ABSTRACT:

Background

The association between cholesterol levels and cerebral edema (CED) or hemorrhagic transformation (HT) as an expressions of blood-brain barrier (BBB) dysfunction after ischemic stroke is not well established. The aim of this study is to determine the association of total cholesterol (TC) levels with the incidence of HT and CED after reperfusion therapies.

Methods

We analyzed SITS Thrombolysis and Thrombectomy Registry data from January 2011 to December 2017. We identified patients with data on TC levels at baseline. TC values were categorized in three groups (reference group ⩾200 mg/dl). The two primary outcomes were any parenchymal hemorrhage (PH) and moderate to severe CED on follow up imaging. Secondary outcomes included death and functional independence (mRS 0

SUBMITTER: Escudero-Martinez I 

PROVIDER: S-EPMC10069196 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature