Mouse Achilles tendons exhibit collagen disorganization but minimal collagen denaturation during cyclic loading to failure.

ABSTRACT: While overuse is a prominent risk factor for tendinopathy, the fatigue-induced structural damage responsible for initiating tendon degeneration remains unclear. Denaturation of collagen molecules and collagen fiber disorganization have been observed within certain tendons in response to fatigue loading. However, no studies have investigated whether these forms of tissue damage occur in Achilles tendons, which commonly exhibit tendinopathy. Therefore, the objective of this study was to determine whether mouse Achilles tendons undergo collagen denaturation and collagen fiber disorganization when cyclically loaded to failure. Consistent with previous testing of other energy-storing tendons, we found that cyclic loading of mouse Achilles tendons produced collagen disorganization but minimal co

SUBMITTER: Pedaprolu K 

PROVIDER: S-EPMC10069227 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature