Social Synchronization of Conditioned Fear in Mice Requires Ventral Hippocampus Input to the Amygdala.

ABSTRACT:

Background

Social organisms synchronize behaviors as an evolutionary-conserved means of thriving. Synchronization under threat, in particular, benefits survival and occurs across species, including humans, but the underlying mechanisms remain unknown because of the scarcity of relevant animal models. Here, we developed a rodent paradigm in which mice synchronized a classically conditioned fear response and identified an underlying neuronal circuit.

Methods

Male and female mice were trained individually using auditory fear conditioning and then tested 24 hours later as dyads while allowing unrestricted social interaction during exposure to the conditioned stimulus under visible or infrared illumination to eliminate visual cues. The synchronization of the immobility or freezin

SUBMITTER: Ito W 

PROVIDER: S-EPMC10069289 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature