Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development.

ABSTRACT: Thyroid hormone is a key regulator of post-embryonic vertebrate development. Skin is a biomedically important thyroid hormone target organ, but the cellular and molecular mechanisms underlying skin pathologies associated with thyroid dysfunction remain obscure. The transparent skin of zebrafish is an accessible model system for studying vertebrate skin development. During post-embryonic development of the zebrafish, scales emerge in the skin from a hexagonally patterned array of dermal papillae, like other vertebrate skin appendages such as feathers and hair follicles. We show here that thyroid hormone regulates the rate of post-embryonic dermal development through interaction with nuclear hormone receptors. This couples skin development with body growth to generate a well ordered array of

SUBMITTER: Aman AJ 

PROVIDER: S-EPMC10069294 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature