Implication of serum growth differentiation factor-15 level in patients with renal diseases.

ABSTRACT:

Background

The synthesis of growth differentiation factor-15 (GDF-15) is induced by inflammation, hypoxia, and oxidative stress and is receiving great interest as a predictive biomarker for cardiovascular disease. However, its detailed impact on patients with renal disease remains uncertain.

Methods

Patients who underwent renal biopsy for evaluation of renal disease between 2012 and 2017 in our institute were prospectively included. Serum GDF-15 levels were measured and its association with baseline characteristics and its impact on the 3-year composites of renal prognosis (composites of > 1.5 folds of serum creatinine and renal replacement therapy) were investigated.

Results

A total of 110 patients (64 [42, 73] years old, 61 men) were included. The median serum GDF-1

SUBMITTER: Kobayashi S 

PROVIDER: S-EPMC10069349 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature