A systematic review of peptide-based serological tests for the diagnosis of leishmaniasis.

ABSTRACT: Serological methods should meet the needs of leishmaniasis diagnosis due to their high sensitivity and specificity, economical and adaptable rapid diagnostic test format, and ease of use. Currently, the performances of serological diagnostic tests, despite improvements with recombinant proteins, vary greatly depending on the clinical form of leishmaniasis and the endemic area. Peptide-based serological tests are promising as they could compensate for antigenic variability and improve performance, independently of Leishmania species and subspecies circulating in the endemic areas. The objective of this systematic review was to inventory all studies published from 2002 to 2022 that evaluate synthetic peptides for serological diagnosis of human leishmaniases and also to highlight the performa

SUBMITTER: Pagniez J 

PROVIDER: S-EPMC10069404 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature