A chromosome-scale epigenetic map of the <i>Hydra</i> genome reveals conserved regulators of cell state.

ABSTRACT: The epithelial and interstitial stem cells of the freshwater polyp Hydra are the best-characterized stem cell systems in any cnidarian, providing valuable insight into cell type evolution and the origin of stemness in animals. However, little is known about the transcriptional regulatory mechanisms that determine how these stem cells are maintained and how they give rise to their diverse differentiated progeny. To address such questions, a thorough understanding of transcriptional regulation in Hydra is needed. To this end, we generated extensive new resources for characterizing transcriptional regulation in Hydra, including new genome assemblies for Hydra oligactis and the AEP strain of Hydra vulgaris, an updated whole-animal single-cell RNA-seq atlas, a

SUBMITTER: Cazet JF 

PROVIDER: S-EPMC10069465 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature